Stable in neutral medium, prone to reversible hydrolysis in hot alkali, and generates lactones when pH returns to neutral. Hydrolysis is slower in acidic medium.
【 Dissolution Status 】
Miscible with water, soluble in methanol, ethanol, ether, acetone, benzene, carbon tetrachloride
Caution for use: As a flammable liquid, be careful to avoid direct contact with fire sources.
Toxicity: Low toxicity. Oral LD50 of mice is 345 mg/kg. It is irritating to the skin.
There are numerous derivatives of 1,4-butyrolactone that can generate different products through various reactions and have a wide range of applications, as follows:
It can be hydrolyzed to produce gamma hydroxybutyric acid, which can be used as a special plasticizer for resins and pharmaceutical intermediates;
Can oxidize to produce succinic acid; Reduce to generate 4-hydroxybutanal, and then reduce to generate 1,4-butanediol;
Can condense to form α, α - dihydroxyketone internal acetals;
Can react with CH3NH2 to generate N-methyl-2-pyrrolidone;
Can generate tetrahydrofuran;
Can react with SO3 to generate butyrolactone - α - sulfonic acid;
Can react with NaCN to generate 2-piperidone;
Can react with CO to produce succinic acid;
Can react with NaOH to produce 4,4-oxosuccinic acid;
Can react with Na2S to generate sulfosuccinic acid;
Can react with NA2SO3 to generate sodium gamma sulfobutyrate.
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